While Ketamine was originally FDA approved for surgical anesthesia, today low-dose intravenous (IV) Ketamine is now frequently used “off-label” due to its positive effects on the various disorders including depression, suicidal ideation, Obsessive Compulsive Disorder (OCD), Post Traumatic Stress Disorder (PTSD), Postpartum Depression (PPD), and several pain syndromes.

Below is a selection of Ketamine studies across a range of mood disorder and pain conditions.

Depression and Ketamine

The Use of Ketamine as an Antidepressant – Systematic Review and Meta-Analysis

Human Psychopharmacology: Clinical and Experimental

Ketamine Administration in Depressive Disorders – A Systematic Review and Meta-Analysis

Psychopharmacology (2014)

The Promise of Ketamine for Treatment-Resistant Depression

Annals of the New York Academy of Sciences (2015)

Ketamine: non-toxic fast and sustained-effect antidepressant

The Benefits of Ketamine Therapy for Depression

Veterans’ Study Shows Effectiveness of Ketamine Against Depression

Ketamine found effective in treating severe depression

Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression

Efficacy of ketamine therapy in the treatment of depression

Ketamine IV: Transformative for People with Suicidal Thoughts

The Washington Post on Ketamine for Depression

My depression resisted treatment for a decade before I found ketamine. Then it was taken away

Penn Medicine Study Gives Peek of How Ketamine Acts as ‘Switch’ in the Brain

Sharon Osbourne says ketamine helped her depression. Is this the next big trend?

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PTSD and Ketamine

Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial

JAMA Psychiatry (2014)

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

Nature Medicine (2021)

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Anxiety and Ketamine

Maintenance Ketamine May Offer Alternative for Patients with Treatment-Refractory Anxiety Disorders

Psychopharmacology (2014)

Emma Stone and IV Glutathione Treatments for Singing

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Pain and Ketamine

Ketamine for chronic non-cancer pain: A meta-analysis and trial sequential analysis of randomized controlled trials

European Journal of Pain(2017)

Ketamine for chronic pain: risks and benefits

British Journal of Clinical Pharmacology (2014)

Ketamine may help treat migraine pain unresponsive to other therapies

American Society of Anesthesiologists (2017)

Jeremy Renner Spends Time in Hyperbaric Oxygen Chamber Twice a Day Following Snowplow Accident

Jay Leno details how his ‘face caught on fire’ in first interview since accident