While Ketamine was originally FDA approved for surgical anesthesia, today low-dose intravenous (IV) Ketamine is now frequently used “off-label” due to its positive effects on the various disorders including depression, suicidal ideation, Obsessive Compulsive Disorder (OCD), Post Traumatic Stress Disorder (PTSD), Postpartum Depression (PPD), and several pain syndromes.

Below is a selection of Ketamine studies across a range of mood disorder and pain conditions.

Depression and Ketamine

The Use of Ketamine as an Antidepressant – Systematic Review and Meta-Analysis

Human Psychopharmacology: Clinical and Experimental

Ketamine Administration in Depressive Disorders – A Systematic Review and Meta-Analysis

Psychopharmacology (2014)

The Promise of Ketamine for Treatment-Resistant Depression

Annals of the New York Academy of Sciences (2015)

---

PTSD and Ketamine

Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial

JAMA Psychiatry (2014)

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

Nature Medicine (2021)

---

Anxiety and Ketamine

Maintenance Ketamine May Offer Alternative for Patients with Treatment-Refractory Anxiety Disorders

Psychopharmacology (2014)

---

Pain and Ketamine

Ketamine for chronic non-cancer pain: A meta-analysis and trial sequential analysis of randomized controlled trials

European Journal of Pain(2017)

Ketamine for chronic pain: risks and benefits

British Journal of Clinical Pharmacology (2014)

Ketamine may help treat migraine pain unresponsive to other therapies

American Society of Anesthesiologists (2017)