While Ketamine was originally FDA approved for surgical anesthesia, today low-dose intravenous (IV) Ketamine is now frequently used “off-label” due to its positive effects on the various disorders including depression, suicidal ideation, Obsessive Compulsive Disorder (OCD), Post Traumatic Stress Disorder (PTSD), Postpartum Depression (PPD), and several pain syndromes.
Below is a selection of Ketamine studies across a range of mood disorder and pain conditions.
Depression and Ketamine
The Use of Ketamine as an Antidepressant – Systematic Review and Meta-Analysis
Human Psychopharmacology: Clinical and Experimental
Ketamine Administration in Depressive Disorders – A Systematic Review and Meta-Analysis
Psychopharmacology (2014)
The Promise of Ketamine for Treatment-Resistant Depression
Annals of the New York Academy of Sciences (2015)
PTSD and Ketamine
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial
JAMA Psychiatry (2014)
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study
Nature Medicine (2021)
Anxiety and Ketamine
Maintenance Ketamine May Offer Alternative for Patients with Treatment-Refractory Anxiety Disorders
Psychopharmacology (2014)
Pain and Ketamine
Ketamine for chronic non-cancer pain: A meta-analysis and trial sequential analysis of randomized controlled trials
European Journal of Pain(2017)
Ketamine for chronic pain: risks and benefits
British Journal of Clinical Pharmacology (2014)
Ketamine may help treat migraine pain unresponsive to other therapies
American Society of Anesthesiologists (2017)
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